Core-shell hydrogel beads with extracellular matrix for tumor spheroid formation
نویسندگان
چکیده
منابع مشابه
Comparision of Different Extracellular Matrix in Mcf7 Tumor Spheroid Formation
Alginate hydrogels have already been extensively used in cell encapsulation, but few investigations have been done to compare cell proliferation and drug response in different extracellular matrices. We previously developed a novel microfluidics approach for tumor spheroid generation and testing: a cellladen core-shell bead suitable for several days of culture, which contains growing spheroids ...
متن کاملGeneration of core-shell microcapsules with three-dimensional focusing device for efficient formation of cell spheroid.
We present a microfluidic device generating three-dimensional (3D) coaxial flow by the addition of a simple hillock to produce an alginate core-shell microcapsule for the efficient formation of a cell spheroid. A hillock tapered at downstream of the two-dimensional focusing channel enables outside flow to enclose the core flow. The aqueous solution in the core flow was focused and surrounded by...
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The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...
متن کاملReinforcement of a decellularized extracellular matrix-derived hydrogel using nanofibers for cardiac tissue engineering
The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...
متن کاملHydrogel Nanofilaments via Core-Shell Electrospinning
Recent biomedical hydrogels applications require the development of nanostructures with controlled diameter and adjustable mechanical properties. Here we present a technique for the production of flexible nanofilaments to be used as drug carriers or in microfluidics, with deformability and elasticity resembling those of long DNA chains. The fabrication method is based on the core-shell electros...
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ژورنال
عنوان ژورنال: Biomicrofluidics
سال: 2015
ISSN: 1932-1058
DOI: 10.1063/1.4918754